The political class in Westminster tend to look at the UK from a London perspective, and to listen especially to the needs of the City of London (i.e., the big financial institutions). Most of the British media exist in the same bubble, which is why so many topics are being discussed as if everybody in the country was making a very comfortable living working in a multinational bank in London.
This became abundantly clear again yesterday, when a majority in Westminster voted to force the UK government to demand an EU budget cut, which is surely another small step towards the Brexit. In other news yesterday, it was noted that the regional divide is growing within England, and Scotland was fully preoccupied with the question of Scottish membership of the EU.
The problem is that London is to a large extent a global Switzerland, and as such EU membership isn't necessarily such a good idea -- a Swiss solution vis-à-vis the EU and lots of bilateral free-trade agreements would probably suit London best.
On the other hand, the rest of the UK is probably not that different from most of Europe, and although we can save Scotland through Scottish independence, I do fear for the prospects of the north of England if London takes the (r)UK out of the EU.
I often think that independence for Greater London would solve even more problems than Scottish independence, but alas it's not on offer.
The current state of affairs is a bit like if the Switzerland and France had formed a union at some point and had moved the capital, the company headquarters, the politicians and the media companies to Zürich, with the result that both parts of the union were being run based on what was best for Zürich. I doubt most of France would have flourished in such a scenario.